ブックタイトルＨ２５博士学位論文_０１１Ｒｅｇｉｎａｌｄ

概要

Ｈ２５博士学位論文_０１１Ｒｅｇｉｎａｌｄ

formerly Verbenaceae) in order to contribute to the establishment of their role asComplementary and/or Alternative Medicine in the Philippines.The use of medicinal plants with anti-diabetic properties continues because of thehigh cost of diabetes treatment. Different investigations on glycemic effects of severalspecies of Ficus, Artocarpus, and Premna have been documented, but that of F.pseudopalma, A. camansi, and P. odorata have not specifically been reported. In BicolRegion of the Philippines the decoction of F. pseudopalma leaves is used for the treatmentof diabetes and kidney stones. In this study the blood glucose lowering effect of the extractof F. pseudopalma was evaluated using sugar/carbohydrate-loaded and normoglycemicmice. The results showed that the hot water extract of the leaves significantly suppressedthe increase of blood glucose levels after glucose, maltose, and starch loading, but it didnot show any hypoglycemic activity in either fasted or non-fasted mice as compared toglibenclamide and metformin. This suggests that F. pseudopalma is potentially useful forthe management of blood glucose levels in the postprandial condition. In the in vitro assayof ??-glucosidase inhibition the extract was found to have a non-competitive type ofinhibition. However, it did not exhibit a significant inhibitory effect on the absorption ofglucose in the small intestines and gastric motility and did not significantly producestimulation of insulin release in vivo.Pharmaceutical companies had developed several anti-hyperglycemic agents thatprimarily control postprandial glucose. Oral agents effective in controlling postprandialhyperglycemia are believed to delay the progression of long-term diabetic complications.Inhibitors of ??-glucosidase that inhibit the intestinal enzyme and cleave polysaccharidesinto monosaccharides, resulting to delayed absorption of carbohydrate after a meal, are thefirst class of oral agents to specifically target postprandial glucose. However, these agentsare known to have several side effects like flatulence and other gastrointestinal symptoms.－５２－