Department of Pharmacy [Department of Pharmacy Laboratories]

Medicinal Resources Chemistry

Academic staff:

  • Associate Professor Michiharu Sugiura, Ph.D.
  • Associate Professor Yoshiaki Takaya, Ph.D.

Research themes:

  1. Discovering medicinal resources through organic chemistry
  2. Discovering bioactive organic compounds and studying their structures

Drug Informatics

Academic staff:

  • Professor Nobuyuki Goto, Ph.D.
  • Associate Professor Fumiko Ohtsu, Ph.D.

Research themes:

  1. Researching the proper use of medicinal products
  2. Identifying risk factors, subjective symptoms, and healthcare economics related to the diagnosis of medicinal side effects
  3. Studying medicines and pharmaceuticals that can meet on-site clinical needs
  4. Developing a database for organizing information on medicinal side effects

Hygiene Chemistry

Academic staff:

  • Professor Nakao Kojima, Ph.D.
  • Assistant Professor Koji Ueda, Ph.D.
  • Assistant Professor Yoshinori Okamoto, Ph.D.

Research themes:

  1. Studying the dynamics of environmental chemicals; how such chemicals interfere with the metabolism and the endocrine system; how their mutagenicity is expressed; and how they can be controlled
  2. Conducting studies related to food hygiene and environmental contamination
  3. Applying pluripotential stem cells to pharmaceutical health chemistry

Environmental Sciences

Academic staff:

  • Professor Ken-ichi Harada, Ph.D.
  • Associate Professor Hideaki Yamaguchi, Ph.D.

Research themes:

  1. Regulating cyanobacteria in aquatic ecosystems
  2. Decomposing environmental pollutants using microorganisms
  3. Deriving anticancer drugs from natural products, in line with ecosystem conservation (Yamaguchi)
  4. Conducting in silico structural analysis of protein-ligand interactions (Yamaguchi)

Functional Molecular Chemistry

Academic staff:

  • Professor Osamu Hara, Ph.D.
  • Assistant Professor Yasuhiro Nishikawa, Ph.D.

Research themes:

  1. Design and application of novel binuclear metal complexes with pyrazole for asymmetric reactions
  2. Development of highly chemoselective oxidation reactions utilizing C-H activation
  3. Development of methodologies applying cationic heteroaromatics for selective activation by electronic charge transfer

Industrial Pharmacy

Academic staff:

  • Professor Toshiyuki Niwa, Ph.D.
  • Assistant Professor Keita Kondo, Ph.D.

Research themes:

  1. Designing nanocrystals by conducting cryogenic grinding in liquid nitrogen
  2. Designing dry nano-suspensions
  3. Developing a new method for producing functional particle pharmaceuticals

Analytical Neurobiology

Academic staff:

  • Professor Norio Kaneda, Ph.D.
  • Associate Professor Tomiyasu Murata, Ph.D.
  • Instructor Kiyomi Hikita, M.S.

Research themes:

  1. Conducting molecular-cell biological studies on the onset mechanism of neurodegenerative disease and cancer
  2. Studying the association of low-molecular-weight N-methyltransferase with Parkinson’s disease
  3. Studying the association of glyoxalase I with neurodegenerative disease and cancer
  4. Examining how the formation of stress granules is associated with intracellular stress-activated response
  5. Elucidating the onset mechanism of type 2 diabetes mellitus resulting from the failure of stress-activated response by pancreatic β cells
  6. Studying the intracellular signal transduction that controls adipocyte differentiation

Biophysical Chemistry

Academic staff:

  • Associate Professor Eiji Kurimoto, Ph.D.

Research themes:

  1. Employing structural biology to study the ubiquitin-proteasome system
  2. Applying protein characteristics to various biosensors

Pharmacognosy

Academic staff:

  • Professor Mitsuhiko Nose, Ph.D.
  • Assistant Professor Shinsuke Hisaka, Ph.D.

Research themes:

  1. Performing scientific analysis of Chinese medicinal prescriptions
  2. Conducting functional analysis of oxidatively modified proteins and studying how they can be controlled by herbal medicines and food-derived factors
  3. Scientifically verifying conventional medical practice and medication and studying how they can be applied to drug discovery
  4. Empirically studying folk remedies and establishing their proper usage

Physiology

Academic staff:

  • Professor Kazunori Yukawa, M.D. & Ph.D.
  • Assistant Professor Kenji Yoshida, Ph.D.
  • Assistant Professor Takayuki Negishi, D.V.M. & Ph.D.

Research themes:

  1. Studying a new action mechanism for the axon guidance molecule Semaphorin
  2. Researching a new action mechanism for the apoptosis-related molecule DAPK
  3. Examining the cause of diabetes insipidus observed among model rats with hereditary cataracts (ICR/f)
  4. Studying the onset mechanism of—and the treatment method for—type 1 diabetes mellitus
  5. Assessing the influence of environmental chemicals on developing brains

Natural Products Chemistry

Academic staff:

  • Professor Hitoshi Tanaka, Ph.D.

Research theme:

  1. Studying biologically active substances present in tropical plants

Microbiology

Academic staff:

  • Professor Toshiaki Nikai, Ph.D.
  • Associate Professor Yumiko Komori, Ph.D.
  • Associate Professor Keiichi Uchiya, Ph.D.

Research themes:

  1. Researching pathogenesis factors of Aspergillosis and inhibitors of those factors
  2. Conducting epidemiological studies on nontuberculous mycobacteria infection based on genetic analysis; identifying pathogenesis factors; and developing a gene-diagnostic method
  3. Analyzing the virulence gene of Salmonella
  4. Developing methods for evidence-based infection control
  5. Studying the structure and function of bioactive substances present in snake venom

Office of Clinical Pharmacy Practice and Health Care Management

Academic staff:

  • Professor Hiroyuki Kamei, Ph.D.
  • Associate Professor Manako Hanya, Ph.D.
  • Assistant Professor Aiko Fukui

Research themes:

  1. Studying proper usage of medicinal products for psychiatric patients; analyzing pathology of mental disorders
  2. Studying interactions between pharmacists and patients
  3. Developing and establishing methods of pharmacotherapy
  4. Developing a methodology for promoting the education of clinical pharmacists

Pathobiochemistry

Academic staff:

  • Professor Shuhei Yamada, Ph.D.
  • Associate Professor Yukiyasu Toyoda, Ph.D.
  • Assistant Professor Shuji Mizumoto, Ph.D.

Research themes:

  1. Functions, structure, biosynthesis, metabolism, and medical application of proteoglycans and glycosaminoglycans
  2. Biochemical studies on the enzymes responsible for the biosynthesis and metabolism of glycans aiming at their medical application
  3. Mechanism of hepatic glucose metabolism in mammals; development of preventives and remedies for diabetes mellitus and obesity
  4. Nutritional assessments of semi-solid enteral nutrients

Molecular Design and Synthesis

Academic staff:

  • Professor Yuji Mori, Ph.D.
  • Assistant Professor Takeo Sakai, Ph.D.

Research themes:

  1. Development of new synthetic reactions using oxiranyl anion as a nucleophilic epoxide
  2. Development of new strategies for the synthesis of oxygen-containing heterocyclic compounds
  3. Total synthesis of bioactive marine polycyclic ethers produced by toxic dinoflagellates
  4. Synthesis and application of new superacid anions
  5. Development of new Lewis acid catalysis characterized by electron-withdrawing cyclopentadienides

Medicinal Chemistry

Academic staff:

  • Professor Shinji Kitagaki, Ph.D.
  • Associate Professor Chihiro Ito, Ph.D.
  • Assistant Professor Naoko Takenaga, Ph.D.

Research themes:

  1. Studying functional molecules based on a novel framework
  2. Developing multicomponent reactions and one-pot reactions toward the efficient synthesis of natural products
  3. Searching for novel anti-tumor substances and anti-tumor promoters in plant resources
  4. Researching seed compounds regarding the differentiation of ES and iPS cells

Analytical Pharmacology

Academic staff:

  • Professor Tadashi Nagamatsu, Ph.D.
  • Associate Professor Ryoji Kojima, Ph.D.
  • Assistant Professor Tomohiro Mizuno, Ph.D.

Research themes:

  1. Studying the onset and progress mechanism of diabetic nephropathy
  2. Researching the structure and functions of a new molecular chaperone, Osp94, and cell cycle-related molecules
  3. Improving pharmacotherapy for treating patients suffering from renal failure

Pharmaceutics

Academic staff:

  • Professor Masayuki Nadai, Ph.D.
  • Associate Professor Miki Katoh, Ph.D.

Research themes:

  1. In vivo and in vitro pharmacokinetic analysis
  2. Research on the nature and mechanism of pharmacokinetic changes in pathological states

Chemical Pharmacology

Academic staff:

  • Professor Masayuki Hiramatsu, Ph.D.
  • Assistant Professor Takayoshi Mamiya, Ph.D.

Research themes:

  1. Elucidation of pathological mechanisms and prevention of dementia, and development of new therapeutic drugs
  2. Studying stress-mediated neuropsychiatric disorders
  3. Development of animal models and new therapies for stress-related diseases
  4. Elucidation of the mechanism underlying drug dependence (methamphetamine and nicotine)

Physical Pharmacy

Academic staff:

  • Associate Professor Yorinobu Yonezawa, Ph.D.

Research themes:

  1. Analyzing the process of drug dissolution and elution from solid preparations
  2. Analyzing the process of drug release from matrix preparations
  3. Designing drug formulations with a focus on dissolution and elution
  4. Designing drug formulations with a focus on release mechanisms

Drug Delivery Research

Academic staff:

  • Professor Hirokazu Okamoto, Ph.D.
  • Assistant Professor Tomoyuki Okuda, Ph.D.

Research themes:

  1. Conducting studies related to the development of inhalants for gene delivery
  2. Studying a new method for formulating inhalants
  3. Studying the proper usage of inhalants

Clinical Medicine

Academic staff:

  • Professor Tsutomu Yoshida, M.D. & Ph.D.

Research themes:

  1. Preventing and treating occupational respiratory disease
  2. Developing a methodology for educating and training clinical pharmacists

Clinical Economics

Academic staff:

  • Professor Hiroyuki Sakamaki, MBA, Dr. Med. Sci.

Research themes:

  1. Researching government policies related to medicinal products; analyzing reimbursement of medical treatment and prescription from the standpoint of medical economics; investigating environmental factors surrounding pharmaceutical companies and pharmacists
  2. Assessing medical technology; analyzing cost effectiveness, medication-related aspects, and duties of pharmacists from the standpoint of medical economics; developing efficacy indicators